Bone Loss in HIV Infection

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Bone disease in HIV infection.

The advent of highly active anti-retroviral therapy (HAART) has dramatically decreased the rate of AIDS-related mortality and significantly extended the life span of patients with AIDS.A variety of metabolic side effects are associated with these therapies, one of which is metabolic bone disease. The causes of low bone mineral density (BMD) in individuals with HIV infection appear to be multifa...

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HIV infection in human bone.

Bone transplantation is often used for the reconstruction of defects. The best results are achieved with autogenous grafts because they induce no immunological reaction, but allogeneic grafts from bone banks are frequently used to provide an adequate volume of bone (Cookson et al 1988). In Germany, about 470 departments using such banks perform about 71 000 autogenous and about 25 000 allogenei...

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Bone health in HIV infection.

INTRODUCTION Osteoporosis is among the chronic problems emerging as the human immunodeficiency virus (HIV)-positive population ages. SOURCES OF DATA We reviewed the English language bibliography using Pubmed 2.0, Web of Science and Embase for relevant abstracts and articles. AREAS OF AGREEMENT The prevalence of low bone mineral density (BMD) and fracture is increased in the HIV-positive pop...

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Bone disease and HIV infection.

The high prevalence of bone demineralization among human immunodeficiency virus (HIV)-infected patients in the current therapeutic era has been described in multiple studies, sounding the alarm that we may expect an epidemic of fragility fractures in the future. However, despite noting high overall prevalences of osteopenia and osteoporosis, recent longitudinal studies that we review here have ...

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Bone alterations during HIV infection.

Osteopenia and osteoporosis are common in HIV-1-infected individuals and represent a challenge in clinical and therapeutic management. Since the mechanisms underlying this degenerative process are largely unsettled and it has not yet been determined whether bone dysfunction is linked to HIV-1-mediated direct and/or indirect effects on osteoblasts/osteoclasts cross-talk regulation, this brief re...

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ژورنال

عنوان ژورنال: Current Treatment Options in Infectious Diseases

سال: 2017

ISSN: 1534-6250

DOI: 10.1007/s40506-017-0109-9